DDR5 graphic cards are much faster and costlier than DDR3 graphic cards and their performance is higher when compared with each other.
Both DDR5 and DDR3 graphic cards requires same Bus Interface
To insert any graphic card, only a PCI x16 port should be available and DDR2 Boards have that facility, so any card can be kept with ease without any problem.
And performance of DDR5 graphic card will be same whether in DDR2 Board or DDR3 board.
Lags can seen while playing games due to the CPU(processor), if its a single core or a dual core.
Here is my GTX 460 GDDR5 Graphic card working on DDR2 Motherboard.
DDR5 = Video Memory of Graphic card Only, it has nothing to do with system.